The effect of glucose concentration on the maturation of stem cell-derived cardiomyocytes
The emergence of methods to induce stem cell differentiation into cardiomyocytes has opened up new avenues for constructing cardiovascular disease models,drug testing,and myocardial regeneration therapy.However,the phenotype of the obtained stem cell-derived cardiomyocytes differs significantly from that of adult cardiomyocytes-specifically manifested by spontaneous contraction,irregular morphology,different sarcomere components,and differ-ences in metabolic patterns.These features may have adverse effects on their clinical application.Therefore,it is cru-cial to develop new strategies to improve the maturity of stem cell-derived cardiomyocytes.This review reviews the main phenotypic differences between stem cell-derived cardiomyocytes and adult cardiomyocytes,with a focus on changes in the metabolic patterns of cardiomyocytes.It also summarizes the effects of changing glucose concentration in the culture medium on the maturation of stem cell-derived cardiomyocytes,in order to provide new ideas for promoting the matura-tion of stem cell-derived cardiomyocytes.
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