The correlation between programmed death ligand 1 expression levels and the proportion of CD163-positive M2 macrophages in the tumor microenvironment of pancreatic cancer
Objective To investigate the correlation between programmed death ligand 1(PD-L1)expression and the infiltration of CD163-positive M2 macrophages in the tumor microenvironment of pancre-atic cancer,aiming to provide new potential targets for immunotherapy.Methods Pancreatic cancer tissue samples were collected and analyzed for PD-L1 and CD163 expression using immunohistochemistry and flow cytometry.Pearson correlation analysis was used to assess the relationship between these markers.Results The results showed a significant positive correlation between high PD-L1 expression and the infiltration level of M2 macrophages in pancreatic cancer tissues(r=0.74,P＜0.01),suggesting that PD-L1 may facilitate immune evasion by promoting M2 macrophage infiltration.Conclusion High PD-L1 expression may en-hance the immunosuppressive function of M2 macrophages,contributing to immune evasion in pancreatic cancer.These findings support a therapeutic strategy targeting both PD-L1 and M2 macrophages.
Pancreatic cancerProgrammed death factor ligand 1M2 macrophagesCD163Immune escape
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