Relationship between preoperative serum long non-coding RNA differentiation antagonizing non-protein coding RNA,forkhead-box O class 1 and prognosis in patients with limbs fracture
Objective To explore the relationship between preoperative serum long non-coding RNA(lncRNA)differentiation antagonizing non-protein coding RNA(DANCR),forkhead-box O class 1(FOXO1)and prognosis in patients with limbs fracture.Methods A total of 120 patients with limbs frac-ture and 60 healthy volunteers who underwent physical examination in Orthopedics and Traumatology Department of Yangzhou Hospital of Traditional Chinese Medicine were enrolled as fracture group and con-trol group between January 2020 and October 2022,respectively.The levels of serum lncRNA DANCR and FOXO1 were compared between the two groups by chi-square test and t-test.After 1 year of follow-up,lev-els of serum lncRNA DANCR and FOXO1 in patients with different prognosis were compared by chi-square test and t-test.The influencing factors of clinical prognosis were analyzed by univariate and Logistic regres-sion analysis.The predictive value of serum lncRNA DANCR and FOXO1 for poor prognosis was analyzed by receiver operating characteristic(ROC)curves.Results The levels of preoperative serum lncRNA DANCR and FOXO1 in fracture group were higher than those in control group[(2.70±0.21)vs.(0.95±0.14),(9.91±1.08)ng/ml vs.(6.24±0.73)ng/ml;t=58.350,23.734,P＜0.05].The levels of preoperative serum lncRNA DANCR and FOXO1 in patients with poor prognosis were higher than those with good prognosis[3.99±0.81 vs.2.25±0.19,(11.59±1.62)ng/ml vs.(9.32±1.04)ng/ml,t=22.389,11.375,P＜0.05].comminuted fracture[(odds ratio(OR)=2.846,95％confidence interval(CI):1.039-7.795,P＜0.05],increased lncRNA DANCR(OR=2.440,95％CI:1.057-5.635,P＜0.05)and FOX01(OR=3.248,95％CI:1.212-8.705,P＜0.05)were risk factors of prognosis.The area under the curve(AUC)values of lncRNA DANCR and FOXO1 for predicting poor prognosis were 0.873 and 0.858,respectively(P＜0.05).Conclusion Preoperative serum lncRNA DANCR and FOXO1 are influen-cing factors of prognosis in patients with limbs fracture,which have good prognostic value.
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