摘要
肿瘤相关成纤维细胞(CAF)是肿瘤微环境的重要组成部分.随着单细胞测序等技术的应用,CAF在肿瘤发生发展中的作用也逐渐得到证实.CAF主要来源于正常成纤维细胞的活化、上皮间质转化、间充质干细胞的募集以及分化和转分化作用.CAF具有明显的分子标记异质性、功能异质性和肿瘤内异质性.CAF通过旁分泌、外泌体或细胞间连接等方式,参与肿瘤免疫、血管新生、细胞外基质重塑等生物学功能,并通过调控多个信号通路,影响肿瘤细胞的增殖、侵袭、转移、化疗耐药等生物学过程.CAF与结直肠癌、胰腺癌、胃癌和肝癌等消化道肿瘤的发生发展关系密切.
Abstract
Cancer-associated fibroblasts(CAFs)are a crucial component of the tumor microenvironment.With the advent of technologies such as single-cell sequencing,the role of CAFs in tumor initiation and progression has been increasingly recognized.CAFs primarily originate from the activation of normal fibroblasts,epithelial-mesenchymal transition,the recruitment and differentiation of mesenchymal stem cells,and transdifferentiation processes.CAFs ex-hibit significant molecular marker heterogeneity,functional diversity,and intra-tumoral variability.They participate in key biological functions such as tumor immunity,angiogenesis,and extracellular matrix remodeling through mecha-nisms like paracrine signaling,exosome release,and intercellular communication.Furthermore,CAFs influence criti-cal cancer cell behaviors,including proliferation,invasion,metastasis,and chemotherapy resistance,by regulating multiple signaling pathways.CAFs play a pivotal role in the development and progression of gastrointestinal malignan-cies such as colorectal cancer,pancreatic cancer,gastric cancer,and liver cancer.
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