摘要
D-二聚体是交联纤维蛋白的降解产物.D-二聚体水平升高提示血液高凝状态和继发性纤溶亢进,可作为凝血与纤溶系统激活的生物标志物,常规用于血栓性疾病的诊断.D-二聚体水平受年龄、妊娠、血糖、感染、肝衰竭、癌症及卒中等因素影响.D-二聚体水平升高与肾脏疾病密切相关.该文通过综述D-二聚体的产生机制及影响因素、D-二聚体与肾脏疾病的关系以及D-二聚体对肾脏疾病患者预后的预测价值,为肾脏疾病的诊断和治疗提供参考.
Abstract
D-dimer is a fibrin degradation product.The increased D-dimer indicates hypercoagulability and secondary hyperfibrinolysis,which can be used as a biomarker for activation of coagulation and fibrinolysis system.D-dimer is routinely used in the diagnosis of thrombotic diseases.D-dimer level is affected by age,pregnancy,blood glucose,infection,liver failure,cancer and stroke.The increased D-dimer is closely related to kidney diseases.The paper reviews the formation mechanism and influencing factors of D-dimer,the relationship between D-dimer and kidney diseases,and the prognostic value of D-dimer in kidney diseases,to provide references for clinical diagnosis and treatment.
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