脓毒症相关急性肾损伤（sepsis associated acute kidney injury，SA-AKI）被定义为脓毒症背景下急性肾损伤（acute kidney injury，AKI）的存在。在遗传易感性的背景下，脓毒症可通过多种机制导致SA-AKI的发生，基于病理生理机制的差异，SA-AKI归属于不同的“内型”，且表现为不同的“亚表型”。生物标志物和预测模型的结合具备早期识别AKI高风险患者和明确SA-AKI“内型”的潜力。容量复苏及血液净化是SA-AKI治疗的优化策略。此外，基于儿童的SA-AKI临床研究值得期待。 Sepsis-associated acute kidney injury (SA-AKI) is defined as the presence of acute kidney injury (AKI) in the context of sepsis. In the setting of genetic susceptibility, sepsis can lead to SA-AKI through various mechanisms. Based on differences in pathophysiological mechanisms, SA-AKI is categorized into different "endotypes" and manifests as distinct "subtypes". The combination of biomarkers and predictive models has the potential to early identify high-risk AKI patients and elucidate SA-AKI "endotypes". Volume resuscitation and blood purification are optimized strategies for SA-AKI treatment. Furthermore, clinical research on SA-AKI in children is promising.
Abstract
Sepsis-associated acute kidney injury (SA-AKI) is defined as the presence of acute kidney injury (AKI) in the context of sepsis. In the setting of genetic susceptibility, sepsis can lead to SA-AKI through various mechanisms. Based on differences in pathophysiological mechanisms, SA-AKI is categorized into different "endotypes" and manifests as distinct "subtypes". The combination of biomarkers and predictive models has the potential to early identify high-risk AKI patients and elucidate SA-AKI "endotypes". Volume resuscitation and blood purification are optimized strategies for SA-AKI treatment. Furthermore, clinical research on SA-AKI in children is promising.
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