肾小管上皮细胞来源外泌体在慢性肾脏病中的研究进展
Advances of renal tubular epithelial cells-derived exosomes in chronic kidney disease
李晨 1王惠明1
作者信息
- 1. 武汉大学人民医院肾内科,武汉 430060
- 折叠
摘要
肾小管上皮细胞(tubular epithelial cells,TECs)作为肾实质的主要组成细胞,在慢性肾脏病(chronic kidney disease,CKD)发生发展过程中发挥多种调节作用.外泌体是由细胞自然分泌的双层膜囊泡,包含蛋白质、核酸和脂质等多种生物活性物质,介导细胞间的信息交流.该文综述了TECs来源外泌体的来源和特征、TECs来源外泌体在CKD肾间质纤维化中的作用以及TECs来源外泌体在CKD诊断中的作用,以期为CKD的预防和治疗提供新的思路.
Abstract
As the most important component of renal parenchyma,tubular epithelial cells(TECs)play numerous regulatory roles in the occurrence and development of chronic kidney disease(CKD).Exosomes,double-membrane vesicles that are naturally secreted by cells,contain various bioactive molecules,including proteins,nucleic acids,and lipids,and serve as mediators for intercellular communications.This article reviewed the sources and characteristics of TECs-derived exosomes,the roles of TECs-derived exosomes affecting renal interstitial fibrosis in CKD,and the roles of TECs-derived exosomes in the diagnosis of CKD,to provide new ideas for the prevention and treatment in CKD.
关键词
肾小管/上皮细胞/外泌体/肾间质纤维化/慢性肾脏病Key words
Kidney tubules/Epithelial cells/Exosomes/Renal interstitial fibrosis/Chronic kidney disease引用本文复制引用
基金项目
国家自然科学基金(82270711)
中国人口福利基金会(SLB-6-20210323-99)
出版年
2024
NETL
NSTL
万方数据