碳酸锂致远端肾小管酸中毒1例并文献复习
Lithium carbonate-induced distal renal tubular acidosis:a case report and literature review
张文军 1郑西希 2叶文玲 2陈丽萌2
作者信息
- 1. 中国医学科学院中国协和医科大学北京协和医院肾内科,北京 100730;山西省阳泉市第一人民医院肾内科,阳泉 045000
- 2. 中国医学科学院中国协和医科大学北京协和医院肾内科,北京 100730
- 折叠
摘要
抗精神病药物锂制剂可引起多种肾脏不良反应,多数隐匿发生.该文报告1例46岁女性病例,服用碳酸锂17年后出现乏力、软瘫,实验室检查表现为低钾血症、远端肾小管酸中毒(distal renal tubular acidosis,dRTA)伴肾结石,停用碳酸锂后低钾血症及dRTA部分缓解.复习文献,锂制剂的肾脏不良反应,除dRTA外,还可表现为急性中毒性肾损伤、肾性尿崩症和肾小球病变等肾脏疾病.
Abstract
Antipsychotics,lithium preparations can cause a variety of renal side effects,most of which occur insidiously.The paper reports a 46-year-old female patient developing fatigue and soft paresis after taking lithium carbonate for 17 years.Laboratory tests showed hypokalemia,distal renal tubular acidosis(dRTA),and renal calculus.After discontinuation of lithium carbonate,partial remission of hypokalemia and dRTA were observed.Combined with literature review,in addition to dRTA,the renal side effects of lithium preparations also include acute toxic kidney injury,nephrogenic diabetes insipidus and various glomerulopathy.
关键词
锂/酸中毒,肾小管性/双相情感障碍/肾脏不良反应Key words
Lithium/Acidosis,renal tubular/Bipolar disorder/Renal side effects引用本文复制引用
出版年
2024
NETL
NSTL
万方数据