异基因造血干细胞移植后合并原钙黏蛋白FAT1相关膜性肾病1例
Allogeneic hematopoietic stem cell transplantation complicated with protocadherin FAT1-associated membranous nephropathy:a case report
王林 1岳书玲 1何建静 2佘旭辉 3揭丽萍 3陆恩峰2
作者信息
- 1. 广州金域医学检验中心病理科,广州 510320
- 2. 中国人民解放军联勤保障部队第九二三医院肾内科,南宁 530021
- 3. 广州金域医学检验中心临床质谱中心,广州 510320
- 折叠
摘要
异基因造血干细胞移植是治疗多种血液系统疾病的有效方法,膜性肾病占移植后新发性肾小球疾病的第2位.原钙黏蛋白FAT1是目前诊断膜性肾病的靶抗原之一,多与造血干细胞移植有关.本文报告1例造血干细胞移植后发生膜性肾病的罕见病例,通过病理联合质谱分析的方法证实膜性肾病的靶抗原是FAT1.通过激素联合环孢素治疗后,肾病综合征达部分缓解,随访过程中患者病情稳定.
Abstract
Allogeneic hematopoietic stem cell transplantation is an effective method for treating various hematological diseases.Membranous nephropathy is the second leading cause of novo glomerular disease after transplantation.Protocadherin FAT1 is a target antigen for diagnosing membranous nephropathy,primarily related to hematopoietic stem cell transplantation.Here we report a rare case of membranous nephropathy after hematopoietic stem cell transplantation.The target antigen of membranous nephropathy was confirmed to be FAT1 by pathology combined with mass spectrometry analysis.The nephrotic syndrome achieved partial remission after corticosteroid combined with cyclosporine treatment,and the patient's condition was stable during follow-up.
关键词
肾疾病/造血干细胞移植/肾小球肾炎,膜性/异基因造血干细胞移植/FAT1Key words
Kidney Diseases/Hematopoietic stem cell transplantation/Glomerulonephritis,membranous/Allogeneic hematopoietic stem cell transplantation/FAT1引用本文复制引用
出版年
2024
NETL
NSTL
万方数据