膜性肾病相关抗原的研究进展
Research advances of membranous nephropathy-associated antigens
王逸枫 1陈瑞颖 1谢琼虹 1郝传明1
作者信息
- 1. 复旦大学附属华山医院肾病科,上海 200040
- 折叠
摘要
膜性肾病(membranous nephropathy,MN)致病抗原的鉴定是肾脏病领域研究的一大热点.近年来,质谱技术的广泛应用给MN致病抗原的鉴定带来了突破性进展.随着抗原谱的逐渐完善,MN的诊断从形态学水平进展到分子水平.该文综述了目前已被鉴定的MN相关抗原,包括原发性MN主要致病抗原磷脂酶A2受体、可能与肿瘤相关的MN抗原1型血小板域蛋白7A、多种继发因素相关的MN抗原神经表皮生长因子样蛋白1、儿童MN相关抗原人类信号素3B等,以及MN相关抗原致病机制和临床意义的研究进展.
Abstract
The identification of pathogenic antigens in membranous nephropathy(MN)is a hot topic in the research field of kidney diseases.In recent years,the widespread application of mass spectrometry has brought a breakthrough in the identification of MN-pathogenic antigens.As the antigen spectrum continues to be refined,the diagnosis of MN has evolved from morphological level to molecular level.This article reviewed the research progress of currently identified antigens of MN,such as phospholipase A2 receptor(a major pathogenic antigen of primary MN),thrombospondin type 1 domain-containing 7A(a potential tumor-associated antigen),neural epidermal growth factor-like protein 1(an antigen associated with various secondary factors),semaphorin 3B(an antigen specific to pediatric MN)and so on,and the pathogenic mechanisms and clinical significance of these antigens.
关键词
膜性肾病/抗原/磷脂酶A2受体Key words
Membranous nephropathy/Antigens/Phospholipase A2 receptor引用本文复制引用
基金项目
国家自然科学基金面上项目(82170735)
国家自然科学基金青年基金项目(82000679)
出版年
2024
NETL
NSTL
万方数据