摘要
目的:肥胖已成为全球严重的健康问题。多项研究表明，慢性腹泻在肥胖人群中较为常见。本研究对肥胖成人中慢性腹泻的患病率进行了系统评价和Meta分析。方法:在PubMed、Embase和Web of Science文献数据库进行了系统检索，检索时间截止至2022年10月15日。本研究纳入了能够计算腹泻患病率的基于人群或肥胖患者的研究，由2名研究人员独立进行研究筛选，数据提取和质量评估。数据采用随机效应模型进行汇总。结果:本研究共评估了8项研究，涉及19 701名受访者，其中11 820名为超重和肥胖个体。身体质量指数(body mass index, BMI)≥25 kg/m2的超重肥胖人群中，慢性腹泻的总体患病率为23.02%(95%CI: 17.47%, 28.57%)。肥胖组(BMI≥30 kg/m2)的腹泻患病率(23.79%，95%CI: 16.29%，31.29%)高于超重组(25 kg/m2≤BMI<30 kg/m2, 18.82%，95%CI: 13.02%，24.62%)，但差异不具有统计学意义(P＝0.30)。结论:慢性腹泻在肥胖人群中相当常见，随着肥胖人数的增加，肥胖与慢性腹泻的共存值得更多关注。
Abstract
Objective:Obesity has become a serious global health concern. A number of studies suggest that chronic diarrhea is frequent in obese people. We performed a systematic review and meta-analysis to assess the prevalence of chronic diarrhea in obese adults.Methods:We systematically searched PubMed, Embase, and Web of Science for studies from inception through October 15, 2022.We included population-based or obese patient-based studies that could calculate the prevalence of diarrhea. Two researchers independently determined study eligibility, extracted data, and assessed quality.Data were pooled using a random effects model.Results:Overall, 8 studies with 19, 701 respondents were assessed, including 11, 820 overweight and obese individuals.The pooled chronic diarrhea rate was 23.02% (95%CI: 17.47%, 28.57%) in people with a BMI≥ 25 kg/m2.The prevalence of diarrhea in the obese group (23.79%, 95%CI: 16.29%, 31.29%) was higher than that in the overweight group (18.82%, 95%CI: 13.02%, 24.62%), but it was not statistically significant (P=0.30).Conclusions:Chronic diarrhea is quite common in obese populations.With the increasing number of obese people, and the coexistence of obesity and chronic diarrhea deserves extra attention.
基金项目
国家重点研发计划(2020YFC2002705-2)
国家重点研发计划(2022YFC2503601)
万方数据