摘要
胃食管反流病(GERD)的临床表现除了反酸、烧心外，还可引起一系列食管外表现，其中，呼吸系统相关疾病发生率高。特发性肺纤维化(IPF)是一种以纤维化、炎症和肺结构破坏为特征的慢性间质性肺疾病，在其发病过程中，胃食管反流所致的长期慢性微量误吸具有重要的作用。本文将从GERD与特发性肺纤维化的相关性、抑酸及抗反流治疗在特发性肺纤维化治疗过程中的作用做一综述。
Abstract
In addition to acid reflux and heartburn, the clinical manifestations of gastroesophageal reflux disease (GERD) can also include a series of extrA-esophageal complications, among which the incidence of respiratory system related diseases is high. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis, inflammation and lung structure destruction. Long-term chronic microaspiration caused by gastroesophageal reflux plays an important role in the pathophysiological process of idiopathic pulmonary fibrosis. This article will review the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis, the role of acid suppression and anti-reflux therapy in the treatment of idiopathic pulmonary fibrosis.
基金项目
国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2022003)
万方数据