枣庄市27例发热伴血小板减少综合征患者流行病学及临床特征分析
Epidemiological and clinical characteristics of 27 patients of severe fever with thrombocytopenia syndrome in Zaozhuang
董棒 1褚雨 2单晨啸 3张旭 4苗璨 4缪玉丹 5杨玉法4
作者信息
- 1. 徐州市贾汪区人民医院,江苏 徐州 221011;枣庄市立医院国家临床药师培训基地,山东 枣庄 277000
- 2. 枣庄市立医院国家临床药师培训基地,山东 枣庄 277000
- 3. 南京中医药大学分析测试中心,江苏 南京 210046
- 4. 徐州市贾汪区人民医院,江苏 徐州 221011
- 5. 徐州市爱心医院,江苏 徐州 223600
- 折叠
摘要
目的 了解枣庄市发热伴血小板减少综合征(SFTS)患者的流行病学及临床特征,为该疾病的科学诊疗提供依据.方法 采用回顾性分析方法,收集2018-2022年枣庄市立医院收治的27例发热伴血小板减少综合征患者流行病学特征、临床表现、实验室检查结果、药物治疗与疾病转归情况进行统计分析.结果 在27例发热伴血小板减少综合征患者中,男性11例,女性16例,平均年龄为(62.56±9.61)岁;职业分布以农民为主,占81.48％(22/27);发病时间集中在4-10月;地区分布以山亭区为主,占48.15％(13/27);12例明确有蜱虫咬伤史.所有患者均有发热,其他主要症状为淋巴结肿大85.19％(23/27),头痛70.37％(19/27),胃肠道不适66.67％(18/27),全身乏力44.44％(12/27).实验室检查结果主要表现为血小板减少27例,白细胞减少21例,D-二聚体升高15例,粒细胞缺乏13例,凝血功能异常13例,肝功能异常10例,降钙素原升高9例,尿蛋白阳性7例.治疗主要采用抗病毒药物联合人血白蛋白,平均住院天数为(10.15±4.22)d,治愈率为92.59％(25/27).结论 发热伴血小板减少综合征在春夏季高发,采用抗病毒药物联合人血白蛋白治疗效果较好.
Abstract
Objective To learn the epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome(SFTS)cases in Zaozhuang,providing evidence for the scientific diagnosis and treatment of the disease.Methods Retrospective analysis was employed.The epidemiological characteristics,clinical manifestations,laboratory examination results,medication and disease outcome of 27 SFTS cases admitted to Zaozhuang Municipal Hospital from 2018 to 2022 were collected and analyzed.Results Of the 27 SFTS cases,11 male and 16 female,with an average age of(62.56±9.61)years,farmers took the main part accounting for 81.48％(22/27).The onset time concentrated from April to October.The cases were mainly from Shanting District,accounting for 48.15％(13/27).12 cases had a clear history of tick bite.All cases had a fever,symptoms mainly as lymph node enlargement 85.19％(23/27),headache 70.37％(19/27),gastrointestinal discomfort 66.67％(18/27),and general fatigue 44.44％(12/27).The laboratory examination showed that,of the 27 cases,27 thrombocytopenia,21 leucopenia,15 D-dimer increase,13 granulocytopenia,13 abnormal coagulation function,10 abnormal liver function,9 procalcitonin increase,and 7 urinary albumen.The patients were medicated mainly antiviral drugs combined with human serum albumin,and hospitalized(10.15±4.22)days in average,with 92.59％(25/27)recovery.Conclusion Fever with thrombocytopenia syndrome occurs mainly in spring and summer.Antiviral drugs combined with human serum albumin are effective.
关键词
发热伴血小板减少综合征/流行病学/临床特征Key words
sever fever with thrombocytopenia syndrome/epidemiology/clinical features引用本文复制引用
基金项目
徐州市卫生健康委科技创新项目(XWKYHT20210525)
出版年
2024
NETL
NSTL
万方数据