Objective To investigate the species composition,density,distribution and seasonal fluctuation of main vectors in Zhengzhou,so as to provide scientific basis for vector control.Methods Rodents were monitored in odd months by night-cage.Adult mosquitoes were monitored by light-trap method from May to October.Flies were monitored by cage-trap method from April to October.Cockroaches were monitored by sticky trap method in odd months.Excel 2010 and SPSS 21.0 software were used for data collection and statistical analysis.Results In 2023,the average density of rodents was 0.33%in Zhengzhou,and the density fluctuation was not obvious with seasonal changes.The density was relatively high in March and November,and the dominant species was Mus musculus.The average density of mosquitoes was 4.68 mosquitoes/lamp·night and reached a peak of 6.48 mosquitoes/lamp·night in July.The dominant species was Culex pipiens pallens.The average density of flies was 9.56 flies/cage,and the seasonal fluctuation showed a bimodal distribution,with peaks in June and September.Musca domestica was the dominant species.The average density index of cockroaches was 7.75 cockroaches/sheet,with peak in November.The dominant species was Blattella germanica.The cockroach infestation rate and density were the highest in the farmers'market.There were no significant difference in the capture rate of rodents,the density of mosquitoes and flies and cockroaches in different habitats(P>0.05).There was no significant difference in the composition ratio of rodents in different habitats(P>0.05),but the composition ratio of mosquitoes and flies in different habitats was different(P<0.05).Conclusion Mus musculus,Culex pipiens pallens,Musca domestica,and Blattella germanica were the dominant species of main vectors in Zhengzhou.Rural and urban residential areas,livestock sheds,and farmers'markets were the focus of prevention and control.Therefore,the control measures should be taken based on the activity patterns of vectors to reduce the occurrence and epidemic of vector-borne infectious diseases.