Objective:To evaluate the relationship between hypokalemia and clinical outcomes in patients with mild and moderate COVID-19 infection.Methods:A total of 125 patients with mild and moderate COVID-19 infection who were not admitted to the Intensive Care Unit (ICU), the Third People’s Hospital of Yangzhou from 4 to 25 August 2021 were selected, including 50 males and 75 females. The mean age was (50.55±19.07) years. A retrospective analysis was performed to study the correlation between hypokalemia and prognosis.Results:The blood potassium levels of the included patients fluctuated between 2.71 and 4.70 mmol/L. Among 125 hospitalized patients, 55(44.00%) developed hypokalemia. The negative time of nucleic acid and the length of hospital stay were significantly prolonged in patients with hypokalemia, and the risk of ICU transfer was significantly increased. Correlation analysis showed that blood potassium level was negatively correlated with the time of negative nucleic acid conversion and the length of hospital stay. Bivariate logistic regression analysis showed that hypokalemia was a risk factor for prolonged negative nucleic acid conversion, prolonged hospital stay, and increased risk of ICU transfer in patients with mild and moderate COVID-19 infection.Conclusion:Hypokalemia is commonly found in patients with mild and moderate COVID-19 infection, and it is associated with prolonged hospital stay.