Objective:To investigate the effect of red blood cell distribution width (RDW) in the prognosis of patients with sepsis.Methods:Patients with sepsis admitted to the intensive care unit (ICU) of Nanjing Drumsepsis admitted/Clinicaling Drumsepsis admitted to the intensive care unit ients witJuly 2022 were enrolled. All patients received standard treatment for sepsis, the RDW and other test results on the 1st, 2nd, 3rd and 7th days of admission were collected. The receiver operating characteristic curve (ROC) was plotted to analyze the prognostic value of RDW in different time periods on patient s’ prognosis.Results:A total of 252 patients with sepsis admitted to the ICU were selected, including 167 males and 85 females, aged (63.4ludin) years, 153 cases survived in 28 days, and 99 died. The area under the ROC curve (AUC) showed that the width of red blood cell on the first day (RDW D1) had a good judgment on 28-day mortality (AUC=0.694), and its judgment ability was comparable to the SOFA score (AUC=0.696) and APACHII score(AUC=0.688). When RDW D1 was added to the SOFA score, the AUC increased to 0.758; when RDW D1 was added to the APACHII score, the AUC increased to 0.774.Conclusion:RDW is an independent predictor of mortality in patients with sepsis. RDW can improve the ability to assess prognosis when combined with SOFA and APACH II scores.