首页|丙泊酚和右美托咪啶对气管插管患者院际转运中镇痛效果的研究

丙泊酚和右美托咪啶对气管插管患者院际转运中镇痛效果的研究

Analgesic effect of propofol and dexmedetomidine on interhospital transport in patients with tracheal intubation

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目的:比较传统镇静剂丙泊酚和新型镇静剂右美托咪啶(Dex)在气管插管患者院际转运过程中的镇静效果。方法:回顾性观察2021年6月至2023年6月通过镇江市急救中心从江苏大学附属医院转运至镇江市外的气管插管的82例患者。根据转运过程中使用的镇静剂,分为丙泊酚组和Dex组。比较转运前后24 h内的血液学指标、APACHEⅡ评分、SOFA评分;转运过程中的不良事件发生率;转运病因、转运距离、转运时间;转院后气管插管时间、ICU住院日、总住院日及28 d病死率。结果:丙泊酚组和Dex组患者在性别、年龄、基础疾病及转运病因等指标的比较,差异均无统计学意义(P>0.05)。转运后的丙泊酚组患者的APACHEⅡ评分显著高于转运前(P<0.05),转运过程中总不良时间发生率,丙泊酚组显著高于右美托嘧啶组,差异有统计学意义(P<0.05);转运后,Dex组患者气管插管时间及总住院时间和丙泊酚组相比差异无统计学意义(P>0.05),ICU住院时间以及28 d病死率明显低于丙泊酚组,差异有统计学意义(P<0.05)。结论:Dex可提高气管插管患者院际转运过程的安全性,改善患者的预后,减轻患者医疗负担。
Objective:To compare the sedative effect of traditional sedative propofol and dexmedetomidine (Dex) in interhospital transport of tracheal intubation patients.Methods:A total of 82 patients with tracheal intubation who were transported from the Affiliated Hospital of Jiangsu University to outside Zhenjiang City by Zhenjiang Emergency Center from June 2021 to June 2023 were retrospectively observed. They were divided into propofol group and Dex group according to the sedative drugs used in the transport process. Hematologic indexes, APACHEⅡ score, SOFA score, incidence of adverse events during transport, transport cause, transport distance, transport time, tracheal intubation time after transfer, ICU stay and total hospital stay and 28-day mortality were compared within 24 hours before and after transport.Results:There was no significant difference between propofol group and Dex group in gender, age, underlying diseases and transport etiology (P>0.05). The APACHEⅡ score of patients in propofol group after transport was significantly higher than that before transport (P<0.05), and the incidence of total adverse time during transport was significantly higher in propofol group than that in dexmetropil group, with statistical significance (P<0.05). After transport, tracheal intubation time and total hospital stay in Dex group had no statistical significance compared with propofol group (P>0.05), but ICU stay time and 28-day mortality were significantly lower than those in propofol group, with statistical significance (P<0.05).Conclusion:Dex can improve the safety of interhospital transport in patients with tracheal intubation, improve prognosis and reduce medical burden.

潘鑫、尹江涛、王超、顾慧、陈伟、孙志伟、王忻、章晋辉

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212003 江苏镇江,镇江市急救中心急救科

212001 江苏镇江,江苏大学附属医院重症医学科

院际转运 丙泊酚 右美托咪啶 气管插管

2021年度镇江市社会发展指导性科技计划项目2021年度"金山英才"高层次领军人才培养计划

FZ2021092镇人才办[2021]19号文件

2023

中华卫生应急电子杂志

中华卫生应急电子杂志

ISSN:
年,卷(期):2023.9(4)
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