Objective:To explore ways to improve the self-efficacy of the "first witness" of out-of-hospital cardiopulmonary resuscitation (CPR), and to provide reference countermeasures for promoting on-site CPR.Methods:From March 2020 to December 2022, the first-aid instructors conducted standardized CPR training outside hospitals, and 486 simulated "first witnesses" who were willing to participate in the study were surveyed with questionnaire on first-aid knowledge, skills and self-efficacy by convenient sampling method after multi-mode network continuous training. The results were compared with 479 cases in the same period of CPR operation training using only simulators.Results:The first-aid knowledge, skills and self-efficacy of the "first witness" in the multi-mode network continuous training were significantly improved (35.09±1.50 in the study group and 23.61±1.47 in the control group), and the willingness to rescue was stronger; the difference was statistically significant (P<0.01).Conclusion:Multi-mode network continuous training can improve first-aid knowledge, skills and rescue willingness of the "first witness", improve self-efficacy, and promote the implementation rate of CPR.