通过动物实验评价一种新型复合刀头的内镜下电切开刀的安全性和有效性。该多功能电切开刀可随时切换Dual刀模式和IT刀模式。制作猪胃组织黏膜病变模型和黏膜下肿瘤模型各30例进行离体实验，选择6只实验用猪各10处胃肠位置进行黏膜病灶切除活体实验。实验组使用多功能电切开刀进行手术，对照组使用Dual刀结合IT刀进行手术，记录手术时间并切取创面观察是否存在肌层损伤。在离体实验中，对胃黏膜病变与胃黏膜下肿瘤病变，实验组手术时间比对照组均缩短［（17.93±2.52）min比（21.07±3.58）min，t=-2.774，P=0.010；（25.73±2.66）min比（31.80±3.78）min，t=-5.081，P<0.001］。在活体实验中，实验组手术时间比对照组缩短［（21.67±4.10）min比（25.36±3.83）min，t=-3.602，P=0.001］，实验组肌层损伤率较低，但差异无统计学意义［3.3%（1/30）比10.0%（3/30），χ²=1.071，P=0.612］。带有复合刀头的多功能内镜下电切开刀在动物体内、体外实验中安全有效。 The safety and efficacy of a compound endoscopic dissection knife were evaluated in animal models. The compound endoscopic dissection knife can readily switch between Dual knife mode and IT knife mode. Vitro experiments were done on 30 mucosal lesion models and 30 submucosal lesion models, respectively, of pig stomach tissue. In vivo experiments, mucosal lesion resection were performed on each 10 lesions of gastrointestinal tract in 6 porcine models. The compound endoscopic dissection knife were used in the experimental group, and Dual knife combined with IT knife were used in the control group. Dissection time were recorded. The wounds were biopsied to evaluate muscle damage. The results of vitro experiment showed the dissection time of mucosal and submucosal lesions in the experiment group was significantly shorter than that in the control group (17.93±2.52 min VS 21.07±3.58 min, t=-2.774, P=0.010 25.73±2.66 min VS 31.80±3.78 min, t=-5.081, P<0.001). The results of vivo experiment showed the dissection time in the experiment group was significantly shorter than that in the control group (21.67±4.10 min VS 25.36±3.83 min,t=-3.602, P=0.001). The muscle damage rate was lower in the experimental group, but the difference was not statistically significant [3.3% (1/30) VS 10.0% (3/30), χ²=1.071, P=0.612]. The compound endoscopic dissection knife is both safe and effective in animal models.
Abstract
The safety and efficacy of a compound endoscopic dissection knife were evaluated in animal models. The compound endoscopic dissection knife can readily switch between Dual knife mode and IT knife mode. Vitro experiments were done on 30 mucosal lesion models and 30 submucosal lesion models, respectively, of pig stomach tissue. In vivo experiments, mucosal lesion resection were performed on each 10 lesions of gastrointestinal tract in 6 porcine models. The compound endoscopic dissection knife were used in the experimental group, and Dual knife combined with IT knife were used in the control group. Dissection time were recorded. The wounds were biopsied to evaluate muscle damage. The results of vitro experiment showed the dissection time of mucosal and submucosal lesions in the experiment group was significantly shorter than that in the control group (17.93±2.52 min VS 21.07±3.58 min, t=-2.774, P=0.010 25.73±2.66 min VS 31.80±3.78 min, t=-5.081, P<0.001). The results of vivo experiment showed the dissection time in the experiment group was significantly shorter than that in the control group (21.67±4.10 min VS 25.36±3.83 min,t=-3.602, P=0.001). The muscle damage rate was lower in the experimental group, but the difference was not statistically significant [3.3% (1/30) VS 10.0% (3/30), χ²=1.071, P=0.612]. The compound endoscopic dissection knife is both safe and effective in animal models.
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