The effect of N-acetylcysteine in relieving discomfort symptoms after esophageal iodine staining
Objective To evaluate the effect of N-acetylcysteine(NAC)in relieving discomfort symptoms after esophageal Lugol's iodine staining.Methods From April 1 to September 30,2023,a total of 204 subjects who received endoscopy at the First Affiliated Hospital of Shihezi University were enrolled.All the subjects were stained with 10 mL 1.5％compound iodine solution after endoscopy.According to random number table method,the 204 subjects were randomly divided into two groups which received 20 mL 0.9％sodium chloride solution(sodium chloride group,103 cases)and 10％NAC(NAC group,101 cases)to neutralize the iodine,respectively.The primary outcome indicators of the subjects of the two groups were analyzed,including the incidence of retrosternal burning sensation and pharyngeal discomfort 15 and 30 min after spraying the neutralization solution,and the degree of discomfort was evaluated by visual analogue scale(VAS).Fisher's exact probability method and non-parametric test were used for statistical analysis.Results The incidence of retrosternal burning sensation and pharyngeal discomfort 15 and 30 min after spraying the neutralization solution in the sodium chloride group were higher than those in the NAC group(15 min:17.5％(18/103)vs.2.0％(2/101),10.7％(11/103)vs.1.0％(1/101);30 min:11.7％(12/103)vs.1.0％(1/101),and 5.8％(6/103)vs.0(0/101)),and the differences were statistically significant(Fisher's exact probability method,P＜0.001,=0.005,=0.003,and=0.029).There was no significant difference in the VAS score 15 min after spraying neutralization solution between the sodium chloride group and the NAC group(3.00(3.00,4.25)vs.4.00(3.00,5.25),P＞0.05).At 30 min after spraying the neutralization solution,the VAS score of the sodium chloride group was higher than that of the NAC group(4.00(3.75,5.00)vs.1.50(1.00,1.50)),and the difference was statistically significant(Z=-2.37,P=0.007).Conclusion NAC can effectively relieve the discomfort caused by esophageal iodine staining.
Early esophageal cancerCompound iodine solutionEsophageal cancer screeningN-acetylcysteine
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