许旺细胞和巨噬细胞作为周围神经组织中的重要成分，其之间的交互调控贯穿于周围神经损伤（PNI）后再生的全程，在瓦勒变性、髓磷脂清除、轴突再生、靶器官再支配等阶段均发挥关键作用。为改善PNI治疗手段单一的现状，关注神经再生过程中许旺细胞和巨噬细胞的交互作用，不断完善PNI修复机制的研究具有重要意义。上海交通大学医学院附属第一人民医院创伤中心通过查阅2015年至2023年国内外有关PNI修复中许旺细胞和巨噬细胞作用机制的文献，总结了许旺细胞和巨噬细胞在PNI后神经再生过程中的交互调控机制，为PNI修复机制的研究和临床治疗提供新思路。 As the important components of peripheral nerve tissue， Schwann cells and macrophages interact with each other throughout the whole process of nerve regeneration。 They play a key role in Wallerian degeneration， myelin clearance， axonal regeneration and target organ reinnervation in promotion of the repair of a peripheral nerve。 In order to improve the simple strategy in treatment of peripheral nerve injury (PNI)， great attention about the significance interaction mechanism between Schwann cells and macrophages in the process of nerve regeneration should be paid， as well as the continuous improvement in researches on the repair mechanism of a PNI。 Trauma Centre， Shanghai General Hospital， Shanghai Jiaotong University School of Medicine summarises the interaction mechanism of Schwann cells and macrophages in the regeneration of PNI through literature reviews， from 2015 to 2023， on the mechanisms of Schwann cells and macrophages in PNI repair， hence to draw new ideas in the research and clinical treatment of PNI。
Interaction between Schwann cells and macrophages during regeneration process after peripheral nerve injury
As the important components of peripheral nerve tissue, Schwann cells and macrophages interact with each other throughout the whole process of nerve regeneration. They play a key role in Wallerian degeneration, myelin clearance, axonal regeneration and target organ reinnervation in promotion of the repair of a peripheral nerve. In order to improve the simple strategy in treatment of peripheral nerve injury (PNI), great attention about the significance interaction mechanism between Schwann cells and macrophages in the process of nerve regeneration should be paid, as well as the continuous improvement in researches on the repair mechanism of a PNI. Trauma Centre, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine summarises the interaction mechanism of Schwann cells and macrophages in the regeneration of PNI through literature reviews, from 2015 to 2023, on the mechanisms of Schwann cells and macrophages in PNI repair, hence to draw new ideas in the research and clinical treatment of PNI.
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