中华心血管病杂志2024,Vol.52Issue(10) :1200-1206.DOI:10.3760/cma.j.cn112148-20230816-00082

中重度心脏瓣膜病患者临床特征分析

Clinical characteristics of patients with moderate or severe valvular heart disease

高昊 雷瑜竹 黄海韵 许祥 张超 朱建芳 李利华 曾敏 陈蜀惠 何锦丽 陈彦秀 张志辉
中华心血管病杂志2024,Vol.52Issue(10) :1200-1206.DOI:10.3760/cma.j.cn112148-20230816-00082

中重度心脏瓣膜病患者临床特征分析

Clinical characteristics of patients with moderate or severe valvular heart disease

高昊 1雷瑜竹 2黄海韵 3许祥 1张超 1朱建芳 1李利华 1曾敏 1陈蜀惠 1何锦丽 1陈彦秀 1张志辉1
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作者信息

  • 1. 陆军军医大学第一附属医院心血管内科代谢生物钟与心血管疾病中心老年心脑血管疾病教育部重点实验室,重庆 400038
  • 2. 陆军第79集团军医院医学影像科,辽阳 111000
  • 3. 陆军军医大学第一附属医院超声科,重庆 400038
  • 折叠

摘要

目的 描述中重度心脏瓣膜病门诊/住院患者的人群特点、病因及瓣膜病变类型.方法 本研究为横断面研究.基于陆军军医大学第一附属医院大数据平台,对2001年1月1日至2020年1月1日门诊及住院首次行超声心动图检查且诊断为中重度心脏瓣膜病患者的年龄、性别特征,病因和瓣膜病变类型等进行描述分析.结果 共纳入中重度心脏瓣膜病患者68354例,年龄63(50,72)岁,其中女性35 706例(52.24%).(1)年龄特征:男性与女性中重度心脏瓣膜病患者数量随年龄变化的趋势相似,均呈先增后减,峰值拐点在65~69岁年龄段.二尖瓣狭窄患病数在45~49岁年龄段达到峰值,较整体前移.二叶式主动脉瓣患者的中位年龄为42岁.(2)性别特征:女性中重度瓣膜病患者中三尖瓣反流、肺动脉瓣反流、二尖瓣反流、二尖瓣狭窄占比以及接受瓣膜手术的比例均明显高于男性,男性中重度瓣膜病患者中主动脉瓣反流、主动脉瓣狭窄及二叶式主动脉瓣的比例高于女性(P均<0.05).(3)病因:风湿性心脏瓣膜病占比13.07%(8 934/68 354),高于退行性病变的0.67%(458/68 354).(4)瓣膜病变类型:三尖瓣反流占比最高[60.72%(41 503/68 354)],此后依次为二尖瓣反流、主动脉瓣反流、二尖瓣狭窄、肺动脉瓣反流、主动脉瓣狭窄.结论 我国西南地区中重度心脏瓣膜病患病情况存在一定的地域性特征,在全程精细化管理上应有所不同.

Abstract

Objective To describe the characteristics,etiology and patterns of outpatients and inpatients patients with moderate or severe valvular heart disease(VHD).Methods This is a cross-sectional study.Outpatients and inpatients with moderate or severe VHD who underwent transthoracic echocardiography for first examination from 1st January 2001 to 1st January 2020 in Southwest Hospital,Army Medical University were enrolled.Data were collected from medical records and big data platform of Southwest Hospital.Characteristics of age and gender,etiology and types of VHD were descriptively analysed.Results A total of 68 354 patients with moderate or severe VHD were enrolled.The age was 63(50,72)years.And 35 706(52.24%)patients were female.(1)Age characteristics:There was similar age trend between male and female patients with moderate or severe VHD.The number of patients increased firstly and then decreased and reached its peak in the age group of 65-69 years old.The peak age of mitral stenosis patients was 45-49 years,which was earlier than that of whole patients with moderate or severe VHD.The median age of patients with bicuspid aortic valve was 42 years.(2)Gender characteristics:The proportion of tricuspid regurgitation,pulmonary regurgitation,mitral regurgitation,mitral stenosis and valve surgery in female patients with moderate or severe VHD were higher than those in male patients.The proportion of aortic regurgitation,aortic stenosis and bicuspid aortic valve in male patients with moderate or severe VHD were significantly higher than those in female patients(all P<0.05).(3)Etiology:The proportion of rheumatic VHD was 13.07%(8 934/68 354),which was higher than that of degenerative VHD(0.67%(458/68 354)).(4)Types of VHD:Tricuspid regurgitation made contribution to the largest proportion with 60.72%(41 503/68 354),followed by mitral regurgitation,aortic regurgitation,mitral stenosis,pulmonary regurgitation and aortic stenosis.Conclusions There are certain regional characteristics in the prevalence of moderate or severe VHD in southwest China,suggesting different attention should be paid on the whole process of refined management of moderate or severe VHD.

关键词

心脏瓣膜疾病/流行病学特征/回顾性分析

Key words

Valvular heart diseases/Epidemiological characteristics/Retrospective studies

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基金项目

重庆英才创新领军人才(医学领域)计划项目(CQYC20210303360)

出版年

2024
中华心血管病杂志
中华医学会

中华心血管病杂志

CSTPCD北大核心
影响因子:2.846
ISSN:0253-3758
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