Clinical analysis on the impact of pretransplant iron overload on allogeneic hematopoietic stem cell transplantation for patients with acquired severe aplastic anemia in pediatric
This study aimed to investigate the effect of iron overload on the transplant outcomes of pediatric patients with severe aplastic anemia(SAA)undergoing allogeneic hematopoietic stem cell transplantation(allo-HSCT).A retrospective analysis was conducted on the clinical data of 74 children with SAA who received allo-HSCT at the Hematology Department of Wuhan Children's Hospital between January 2018 and August 2022.Children with iron overload(serum ferritin＞1 000 μg/L)before transplantation had a longer disease course,received more red blood cell transfusions,and had a higher number of CD34+cells infused.Moreover,iron overload significantly delayed the reconstitution of regulatory T cells after transplantation,increasing the incidence of hemorrhagic cystitis and grade Ⅲ-Ⅳacute graft-versus-host disease after transplantation.However,iron overload did not significantly affect the overall survival and failure-free survival rates of the children.
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