摘要
探讨铁过载对治疗重型再生障碍性贫血(SAA)患儿异基因造血干细胞移植(allo-HSCT)疗效的影响.通过对武汉儿童医院血液科2018年1月至2022年8月间接受allo-HSCT的74例SAA患儿的临床资料进行回顾性分析,发现移植前铁过载组[血清铁蛋白(SF)＞1 000 μg/L]患儿移植前病程更长、红细胞输注量更大、回输CD34+细胞数更多,且铁过载显著延迟了移植后调节性T细胞(Treg细胞)的重建,增加了移植后出血性膀胱炎和Ⅲ～Ⅳ度急性移植物抗宿主病的发生率.然而,铁过载对患儿的总生存率和无失败生存率并无显著影响.
Abstract
This study aimed to investigate the effect of iron overload on the transplant outcomes of pediatric patients with severe aplastic anemia(SAA)undergoing allogeneic hematopoietic stem cell transplantation(allo-HSCT).A retrospective analysis was conducted on the clinical data of 74 children with SAA who received allo-HSCT at the Hematology Department of Wuhan Children's Hospital between January 2018 and August 2022.Children with iron overload(serum ferritin＞1 000 μg/L)before transplantation had a longer disease course,received more red blood cell transfusions,and had a higher number of CD34+cells infused.Moreover,iron overload significantly delayed the reconstitution of regulatory T cells after transplantation,increasing the incidence of hemorrhagic cystitis and grade Ⅲ-Ⅳacute graft-versus-host disease after transplantation.However,iron overload did not significantly affect the overall survival and failure-free survival rates of the children.
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