Hemophagocytic syndrome secondary to invasive NK cell leukemia and T-cell lymphoma treated with the modified MINE protocol:report of three cases and literature review
Lymphoma-associated hemophagocytic syndrome is aggressive with rapid progression,particularly in NK/T cell lymphoma.The MINE regimen is a salvage treatment for aggressive non-Hodgkin lymphoma.In our center,the modified MINE regimen was applied to treat three patients with hemophagocytic syndrome secondary to aggressive NK cell leukemia and T-cell lymphoma.The modified MINE regimen showed good efficacy against NK/T cell lymphoma,control of the inflammatory state of secondary hemophagocytic syndrome,and good tolerability.
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