The application of tyrosine kinase inhibitors and targeted immunotherapy has revolu-tionized the therapeutic strategies and clinical outcome for BCR∷ABL1-positive B-cell acute lymphoblas-tic leukemia(BCR∷ABL1+B-ALL).The classification was updated successively by the World Health Or-ganization and the International Consensus Classification in 2022.The risk stratification of this entity,for the first time,was modified by the National Comprehensive Cancer Network in 2023,both minimal residu-al disease assessment and IKZF1plus genotyping recognized as critical prognostic factors.These important updates would have significant implications for clinical management.Therefore,this review focused on the latest advances in the classification and prognostic evaluation of BCR∷ABL1+B-ALL.
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