摘要
血液病患者易发感染,且感染相关死亡率较高,感染病原的准确诊断至关重要,但常规微生物检测难以满足临床需求,成为临床面临的重要难题.宏基因组二代测序(mNGS)因其高灵敏度、广覆盖及检测周期短的特点,已在感染性疾病诊断中获得广泛应用.本文聚焦mNGS技术在血液病患者感染病原诊断中的应用现状,分析其在临床中面临的挑战和未来发展趋势,旨在帮助临床医师深入认识该技术在血液病感染诊断中的价值及局限性,以实现合理应用.
Abstract
Patients with hematologic diseases are prone to infections,and infection-related mortality is high in this population.Accurate diagnosis of infectious pathogens is crucial;however,conventional microbiological testing often fails to meet clinical needs,presenting a significant challenge in clinical practice.Metagenomic next-generation sequencing(mNGS),with its high sensitivity,broad coverage,and short turnaround time,has been widely adopted in diagnosing infectious diseases.This article focuses on the application of mNGS technology in diagnosing infectious pathogens in patients with hematologic diseases.It analyzes the challenges encountered in clinical practice and explores future trends in the field.This work aims to provide clinicians with an in-depth understanding of the value and limitations of mNGS in diagnosing infections in hematologic patients,and to promote its rational application.
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