Maribavir treatment for refractory and drug-intolerant cytomegalovirus viremia and disease after allogeneic hematopoietic stem cell transplantation:a clinical analysis of 25 cases
Objective To investigate the safety and efficacy of maribavir for the treatment of CMV viremia and CMV disease refractory or intolerant to conventional antiviral drugs after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods This study retrospectively analyzed the clinical characteristics and outcomes of CMV viremia and CMV disease refractory or intolerant to conventional antiviral drugs after allo-HSCT treated with maribavir at Hebei Yanda Lu Daopei Hospital from April 2024 to September 2024.Result A total of 25 patients received maribavir,including 21 haploidentical transplants,two sibling HLA-matched transplants,and 2 HLA-matched unrelated transplants.Among them,21,2,and 2 patients received the first,second,and third transplants,respectively.The median time to the onset of CMV viremia and CMV disease was 120.5(6-298)days post-transplantation.The median peak plasma CMV copy number was 6 400 copies/ml(range:1 100-650 000 copies/ml).Six patients were diagnosed with CMV disease.Maribavir was administered after a median of 9.5(1-41)days after CMV infection.The median duration of maribavir administration was 11.5(6-43)days.Post-treatment,maribavir was effective in 25(100％)patients.Two patients experienced grade 1 taste abnormalities,and one patient experienced grade 2 myelosuppression.Conclusion The application of maribavir after allo-HSCT for treating refractory,drug-intolerant CMV viremia and CMV disease is safe and effective.
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