2007-2010年新疆维吾尔自治区汉族、维吾尔族、哈萨克族35岁以上人群空腹血糖水平与颈动脉内中膜厚度的相关性研究
Association between the level of fasting blood glucose over 35-year-old and carotid intima-media thickness in Han, Uygur and Kazak population from Xinjiang Uygur Autouomous Region from 2007 to 2010
李晓梅 1李海霞 2刘芬 3陈邦党 3杨毅宁 4马依彤4
作者信息
- 1. 830011 乌鲁木齐,新疆医科大学第一附属医院心脏中心
- 2. 830011 乌鲁木齐,新疆医科大学第一附属医院心脏中心;山东省中西医结合医院山东中医药大学第二附属医院心内科
- 3. 新疆医科大学第一附属医院第一临床医学院
- 4. 新疆医科大学第一附属医院心脏中心
- 折叠
摘要
目的 分析新疆维吾尔自治区汉族、维吾尔族、哈萨克族≥35岁人群FBG水平与颈动脉内中膜厚度(IMT)的相关性.方法 于2007年10月至2010年4月,按照多阶段分层整群随机抽样原则,在新疆维吾尔自治区的7个市(州、地区)选取汉族、维吾尔族、哈萨克族≥35岁常住人群,排除颈动脉内中膜增厚(IMT ＞0.9 mm)者及长期外出、流动人口,共获得有效调查对象13 935名.测量其FBG及颈动脉IMT值,根据FBG值将调查对象分为FBG正常组、空腹血糖受损(IFG)组、糖尿病组.采用方差分析比较不同组别颈动脉IMT的差异,采用多元线性回归模型探讨颈动脉IMT的影响因素.结果 汉族、维吾尔族、哈萨克族男性颈动脉IMT分别为(0.81 ±0.29)、(0.71±0.27)、(0.79 ±0.21)mm(F=88.50,P＜0.05),其糖尿病组颈动脉IMT为(0.82±0.29) mm,高于FBG正常组[(0.77±0.26) mm]和IFG组[(0.79±0.27) mm] (F=7.49,P ＜0.05).汉族、维吾尔族、哈萨克族女性颈动脉IMT分别为(0.72±0.27)、(0.63±0.25) 、(0.77±0.22)mm(F=173.93,P＜0.05),其糖尿病组和IFG组颈动脉IMT分别为(0.75±0.29)、(0.74 ± 0.26) mm,均高于FBG正常组[(0.70±0.25) mm] (F=10.46,P＜0.05).舒张压(β'=0.101,P＜0.05)、TC(β'=0.056,P ＜0.05) 、FBG(β'=0.023,P =0.009)是颈动脉IMT的独立影响因素.结论 新疆维吾尔自治区汉族、维吾尔族、哈萨克族≥35岁人群FBG水平是颈动脉IMT的独立影响因素,且两者呈正相关.
Abstract
Objective To analyze the relationship between different levels of fasting blood glucose over 35-year old and carotid intima-media thickness (IMT) in Han,Uygur and Kazak adult population from Xinjiang Uygur Autonomous Region.Methods From October 2007 to April 2010,the present study was performed in 13 935 inhabitants among Han,Uygur and Kazak adult population of aged 35 years old and over by multi-stage stratified cluster random sampling principles from 7 regions in Xinjiang Uygur Autonomous and we excluded the IMT over 0.9 millimeter,long-term out and the floating population.All subjects were measured fasting blood glucose and IMT values of carotid artery.The subjects were divided into three groups according to different fasting blood glucose levels:normal,impaired fasting glucose (IFG) and diabetes mellitus (DM) and we used the analysis of variance to compare the differences among groups of IMT.Multiple linear regression model was used to explore factors of carotid IMT.Results The IMT of males of Han,Uygur and Kazak were (0.81 ± 0.29),(0.71 ± 0.27) and (0.79 ± 0.21) mm respectively,the differences were significant (F =88.50,P ＜ 0.05).The IMT in DM group ((0.82 ± 0.29) mm) was significantly higher than the normal((0.77 ±0.26) mm) and the IFG groups((0.79 ±0.27) mm) (F =7.49,P ＜ 0.05).The IMT of females of Han,Uygur and Kazak were (0.72 ± 0.27),(0.63 ± 0.25) and (0.77 ± 0.22) mm,respectively,the differences were significant (F =173.93,P ＜ 0.05).The 1MT in DM group ((0.75 ± 0.29) mm) and the IFG groups ((0.74 ± 0.26) mm) were significantly higher than the normal group((0.70 ± 0.25) mm) (F =10.46,P ＜ 0.05).Multivariate regression analysis showed that diastolic blood pressure(β =0.101,P ＜ 0.01),total cholesterol(β =0.056,P ＜ 0.05) and fasting blood glucose(β =0.023,P =0.009) were independent risk factors of IMT.Conclusion The level of fasting blood glucose was an independent influence factor of carotid IMT and had a positive correlation in Han,Uygur and Kazak population of Xinjiang Autonomous Region.
关键词
颈动脉/血糖/糖尿病/维吾尔族/哈萨克族Key words
Carotid arteries/Blood glucose/Diabetes mellitus/Uygur/Kazak引用本文复制引用
基金项目
新疆维吾尔自治区科技支撑计划(201251338)
出版年
2014
NETL
NSTL
维普
万方数据