变应性鼻炎（AR）发病率逐年增高，儿童尤为明显。AR不仅影响患儿的生长发育、生活和学习，同时还会造成巨大的经济和社会负担，本文从儿童AR受基因多态性、表观遗传学、炎症反应机制、微生态影响机制等个人方面内因对疾病的影响；以及变应性因素、环境空气污染物因素、感染和免疫因素、气候及气候变化等外因对疾病的影响进行综述，旨在提高对儿童AR的认识，以期为其预防及治疗提供依据。 The incidence of allergic rhinitis (AR) is increasing year by year, especially in children. AR not only affects the growth, development, life and learning of children but also causes huge economic and social burdens. This study explores the impact of individual factors such as genetic polymorphisms, epigenetics, inflammatory response mechanisms, and microecological influence mechanisms on children′s AR. It also reviews the impact of external factors such as allergenic factors, ambient air pollutants, infection and immunity factors, and climate and climate change on the disease, with the aim of improving understanding of AR in children and providing a basis for its prevention and treatment.
Research progress on influencing factors of allergic rhinitis in children
The incidence of allergic rhinitis (AR) is increasing year by year, especially in children. AR not only affects the growth, development, life and learning of children but also causes huge economic and social burdens. This study explores the impact of individual factors such as genetic polymorphisms, epigenetics, inflammatory response mechanisms, and microecological influence mechanisms on children′s AR. It also reviews the impact of external factors such as allergenic factors, ambient air pollutants, infection and immunity factors, and climate and climate change on the disease, with the aim of improving understanding of AR in children and providing a basis for its prevention and treatment.
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