蟑螂是全球最常见的室内过敏原之一,蟑螂过敏原(虫体、残骸、分泌物等)的暴露和致敏可诱发严重的过敏性鼻炎和(或)哮喘.目前,WHO(World Health Organization)/IUIS(International Union of Immunological Societies)在蟑螂中已鉴定出32种过敏原组分,但是这些过敏原均未显示出蟑螂明确的免疫优势过敏原.蟑螂过敏原的致敏率在不同地区和人群中显示出显著的差异性,并且与多种无脊椎动物存在交叉反应性,增加了临床诊断和治疗的复杂性.本文通过深入解读欧洲过敏和临床免疫学会(EAACI)发布的《过敏原组分诊断指导建议2.0》以及国内外关于蟑螂过敏的研究进展,阐明过敏原组分诊断技术在提升与改善蟑螂诱发的过敏性疾病诊疗中的关键作用,高效协助临床识别蟑螂与其他过敏原之间的共同致敏与交叉反应,从而为患者提供更加精准的诊断和个性化治疗方案.
From exposure to control:the application of allergen component-resolved diagnosis in the clinical management of cockroach allergies
Cockroaches are one of the most common indoor allergens worldwide,and exposure to cockroach allergens(such as the insect body,debris,and secretions)can trigger severe allergic rhinitis and(or)asthma.Currently,the World Health Organization(WHO)/International Union of Immunological Societies(IUIS)has identified 32 allergenic components in cockroaches,but none of these allergens have shown a clear immunodominance.The sensitization rate to cockroach allergens shows significant variability across different regions and populations and exhibits cross-reactivity with various invertebrates,increasing the complexity of clinical diagnosis and treatment.This article delves into the"Molecular Allergology User's Guide 2.0"(MAUG 2.0)published by the European Academy of Allergy and Clinical Immunology(EAACI)and the research progress on cockroach allergies both domestically and internationally.It elucidates the crucial role of allergen component diagnostic technology in enhancing the diagnosis and treatment of cockroach-induced allergic diseases,efficiently assisting clinicians in identifying common sensitizations and cross-reactivities,thereby offering patients more accurate diagnoses and personalized treatment plans.
Cockroach allergiesComponent-resolved diagnosisBlattella germanicaPeriplaneta americana
万方数据
维普
