度普利尤单抗相关周边溃疡性角膜炎1例
Peripheral ulcerative keratitis associated with dupilumab:a case report
龙泽 1李明顺1
作者信息
- 1. 北京医院眼科 国家老年医学中心 中国医学科学院老年医学研究院,北京 100730
- 折叠
摘要
1例68岁男性患者因重度特应性皮炎接受度普利尤单抗治疗后约6周,出现双眼异物感、右眼畏光及流泪,右眼周边部角膜可见一新月形浅基质溃疡,边缘呈潜行性,与角膜缘有透明区域相隔,左眼角膜缘血管翳.角膜刮片、细菌及真菌培养等检查除外感染,给予0.1％氟米龙滴眼液点右眼、重组牛碱性成纤维细胞生长因子滴眼液点双眼治疗.随访期间病情持续好转,初诊82 d后复诊可见右眼角膜病灶基本愈合,矫正视力由0.5提高到1.0.
Abstract
A 68-year-old male developed foreign body sensation in both eyes,photophobia and tearing in the right eye approximately 6 weeks after initiating dupilumab for severe atopic dermatitis.The right eye presented a crescent-shaped superficial-stromal ulcer in the peripheral cornea with an undermined edge,which was separated from the limbus of the cornea by a clear zone.The left eye had a pannus at the limbus of the cornea.Corneal scraping,bacterial culture,and fungal culture excluded infections.The patient was administered 0.1％fluorometholone eye drops and recombinant bovine basic fibroblast growth factor eye drops.The patient's condition continued to improve during the follow-up period.At the revisit 82 days after the initial diagnosis,the corneal lesions of the right eye were basically healed,and the corrected visual acuity increased from 0.5 to 1.0.
关键词
角膜溃疡/抗体,单克隆,人/特应性皮炎Key words
Corneal ulcer/Antibodies,monoclonal,humanized/Dermatitis,atopic引用本文复制引用
出版年
2025
NETL
NSTL
万方数据