摘要
幼年特发性关节炎相关葡萄膜炎(JIA-U)是幼年特发性关节炎(JIA)常见的关节外表现。JIA-U通常表现为慢性前葡萄膜炎,发病隐匿,常伴随威胁视力的并发症。JIA-U治疗主要为控制JIA-U眼内炎症至无或最小活动态,并保持其静止,从而避免多种并发症的发生。了解JIA-U的发病机制和相关危险因素,可有利于及时治疗和最大程度地降低患者的视力损害程度。因此,本文中笔者现就JIA-U的流行特点、发病机制、临床表现、诊断及治疗进展进行综述。
Abstract
Juvenile idiopathic arthritis associated uveitis (JIA-U) is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA). JIA-U usually is characterized by chronic anterior uveitis, with insidious onset and often companying with vision-threatening complications. The goal of treatment for JIA-U is to reduce intraocular inflammation to zero or minimal activity to maintain immobility, which to be avoided various kinds of complications of JIA-U. It is of great benefit for ophthalmologists to understand the pathogenesis of JIA-U and associated risk factors, which to timely treat and reduce visual impairment with the greatest degree of effort. Therefore, the epidemic characteristics, pathogenesis, clinical manifestations, diagnosis and treatment of JIA-U were reviewed in this paper.