摘要
免疫性眼表疾病是一类由特定抗原刺激眼表，引起眼表组织发生免疫性炎症反应并导致一系列临床症状的眼部疾病。眼表菌群对维持眼表稳态、促进眼健康及维持机体免疫方面具有重要的辅助作用。正常情况下，人体眼表微生物群落相对稳定；反之，眼表菌群异常增殖和平衡紊乱会诱发各种眼表疾病的发生。本文中笔者从微生态角度对干燥综合征、过敏性结膜炎、Steven－Johnson综合征、移植物抗宿主病及黏膜相关淋巴组织淋巴瘤等常见免疫性眼表疾病眼表菌群的变化规律进行综述。
Abstract
Immune ocular surface disease is a kind of ocular diseases caused by the stimulation of ocular surface by specific antigen, which leads to immune inflammatory reactions and a series of clinical symptoms. Ocular surface microflora plays an auxiliary role in maintaining ocular surface homeostasis, promoting eye health and maintaining body immunity. Under normal circumstances, the human eye surface microbial community is relatively stable; otherwise, the abnormal proliferation and imbalance of ocular surface bacteria has the capacity of bringing out various ocular surface diseases. The changes of ocular surface flora in different immune ocular surface diseases including Sjögren syndrome, allergic conjunctivitis, Stevens-Johnson syndrome, Graft-versus-host disease and mucosa-associated lymphoid tissue lymphoma from the perspective of microecology were reviewed in this paper.
基金项目
国家自然科学基金面上项目(81970765)
国家重点研发计划项目(2021YFC2301000)
万方数据