摘要
近年来，有研究结果表明人葡萄膜中的虹膜色素上皮细胞具有对脂多糖(LPS)反应的固有模式识别受体，包括Toll样受体(TLR)4、髓样分化蛋白(MD)2及分化簇(CD)14。这一发现扩展了微生物触发因子和葡萄膜固有免疫在急性前葡萄膜炎发病机制中的解释。提示LPS受体复合物成分可能成为该病的治疗靶点。本文中笔者对LPS受体复合体在人虹膜色素上皮细胞和葡萄膜炎动物模型中的研究现状进行综述。
Abstract
Recently, it has been demonstrated that iris pigment epithelial cells of human uveal have had inherent pattern recognition receptors for the lipopolysaccharide response (LPS), such as Toll-like receptor (TLR)4, myeloid differential protein (MD)-2 and cluster of differentiation (CD)14, which expanding the current understanding of microbial triggers and uveal innate immune in the pathogenesis of acute anterior uveitis. The result point out components of the LPS receptor complex may serve as effective targets for the treatment. The research status of LPS receptor complex in human iris pigment epithelial cells and uveitis in animal models were reviewed.
基金项目
甘肃省自然科学基金资助项目(17JR5RA225)
甘肃省高等学校创新基金(2021B-023)
万方数据