摘要
后发性白内障(PCO)是白内障囊外摘除术和超声乳化白内障吸除术后的主要并发症。现有研究发现，术后残留晶状体上皮细胞，上皮－间充质转化(EMT)是PCO形成的主要原因，其发病机制涉及众多信号通路、细胞因子、生长因子、蛋白酶及整合素的参与；而PCO的防控现有手段有激光治疗、药物治疗、人工晶状体(IOL)材料改性以及基因治疗等多种措施。本文中笔者就当前PCO的发病机制及防控措施进行评述。
Abstract
Posterior cataract (PCO) is the main complication after extracapsular cataract extraction and phacoemulsification. It has demonstrated that residual lens epithelial cell epithelial mesenchymal transition (EMT) after surgery is the main cause of PCO formation, and its pathogenesis involves the involvement of numerous signaling pathways, cytokines, growth factors, proteases, and integrins. The existing methods for preventing and controlling PCO include laser therapy, drug therapy, modification of intraocular lens (IOL) materials, and gene therapy. The current pathogenesis and prevention and control measures of posterior cataract were reviewed in this paper.
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