Logistics is the key element to determine the advancement of business,and also the main cause for the rapid de-velopment and continuous innovation of Retailing and E-commerce in China in the past decade.This paper reviews the innovative exploration of building the Shanghai Kedi logistics center,summarizes the construction and management experience of construc-ting over two hundred logistics centers worldwide,and proposes a brand-new retail logistics model based on virtual business the-ory,i.e.,RL-VB model.We present the methodology of informationization construction,system framework,logistics informa-tion platform,elements of logistics management,integrated method,management path and operational orientation of RL-VB model,and demonstrate its practicality,systematicness and progressiveness from the perspective of system engineering.The successful practical application of RL-VB model in hundreds of business groups shows that it effectively improves the logistics operations of retailing enterprises,and supports the rapid progress and healthy development of business in China.Finally,the paper points out that the key to the success of RL-VB model is to proceed from the reality and base on the local,and insist on de-velopment through self-innovation.