Advances research of clinical characteristics and mechanisms of cholelithiasis in patients with inflammatory bowel disease
石钰洁 1李玥 1周静
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作者信息
1. 中国医学科学院 北京协和医学院 北京协和医院消化内科，北京 100730
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摘要
胆石症是炎症性肠病（IBD）患者常见的共患疾病之一，由于其发病率显著高于普通人群，且胆结石引起的胆囊炎、胰腺炎、胆囊癌等并发症增加疾病负担，值得临床医生关注。本文对IBD患者胆石症的发生率、发生机制及危险因素等临床特点进行综述，发现IBD患者胆石症的发生机制可能与胆汁酸肠肝循环受损、胆囊动力减低等相关，性别、年龄、病程、病变部位及肠道手术是其危险因素。 Cholelithiasis is one of the common comorbidities in patients with inflammatory bowel disease (IBD). It has a significantly higher incidence in IBD than the general population, and the complications caused by gallstones such as cholecystitis, pancreatitis, and gallbladder carcinoma increase the burden of the disease, which deserves the concern of clinicians. This article provides a comprehensive review of the clinical characteristics of cholelithiasis in IBD patients, including its incidence, mechanisms, and risk factors. It suggests that the mechanisms of cholelithiasis in IBD patients may be related to impaired enterohepatic circulation of bile acids and decreased gallbladder motility, and risk factors include gender, age, disease duration, affected site, and intestinal surgery.
Abstract
Cholelithiasis is one of the common comorbidities in patients with inflammatory bowel disease (IBD). It has a significantly higher incidence in IBD than the general population, and the complications caused by gallstones such as cholecystitis, pancreatitis, and gallbladder carcinoma increase the burden of the disease, which deserves the concern of clinicians. This article provides a comprehensive review of the clinical characteristics of cholelithiasis in IBD patients, including its incidence, mechanisms, and risk factors. It suggests that the mechanisms of cholelithiasis in IBD patients may be related to impaired enterohepatic circulation of bile acids and decreased gallbladder motility, and risk factors include gender, age, disease duration, affected site, and intestinal surgery.
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