Optimal management of inflammatory bowel disease during the COVID-19 epidemic
简易成 1冉志华 1古敏怡
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作者信息
1. 上海健康医学院附属周浦医院消化科，上海 201318
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摘要
本综述旨在总结目前关于新型冠状病毒肺炎（简称"新冠肺炎"）在炎症性肠病（IBD）患者中的风险和影响的证据，并讨论在此疫情期间IBD的优化管理。IBD患者并没有更高的新冠肺炎发病率，也不伴更严重的疾病进展。多种因素与新冠肺炎感染风险增加、住院率增加和严重新冠肺炎风险增加相关。IBD的治疗与更严重的新冠肺炎无关，5-氨基水杨酸和硫唑嘌呤与新冠肺炎的风险增加的关系尚有争议。不同类别和疾病程度的IBD患者治疗方案需要调整。新冠肺炎疫苗对IBD患者是有效和安全的。 This review aims to summarize the current evidence on the risk and impact of coronavirus disease 2019 (COVID-19) in patients with inflammatory bowel disease (IBD), and to discuss optimal management of IBD during this outbreak. IBD patients did not have a higher incidence of COVID-19 or more severe disease progression. Multiple factors are associated with an increased risk of COVID-19 infection, increased hospitalization rate, and increased risk of severe COVID-19. Treatment of IBD is not associated with more severe COVID-19, and the association of 5-aminosalicylic acid and thiopurine with increased risk of COVID-19 is controversial. Treatment regiments for IBD patients with different categories and levels of disease need to be adjusted during the epidemic. COVID-19 vaccine is effective and safe for patients with IBD.
Abstract
This review aims to summarize the current evidence on the risk and impact of coronavirus disease 2019 (COVID-19) in patients with inflammatory bowel disease (IBD), and to discuss optimal management of IBD during this outbreak. IBD patients did not have a higher incidence of COVID-19 or more severe disease progression. Multiple factors are associated with an increased risk of COVID-19 infection, increased hospitalization rate, and increased risk of severe COVID-19. Treatment of IBD is not associated with more severe COVID-19, and the association of 5-aminosalicylic acid and thiopurine with increased risk of COVID-19 is controversial. Treatment regiments for IBD patients with different categories and levels of disease need to be adjusted during the epidemic. COVID-19 vaccine is effective and safe for patients with IBD.
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