基于图论的炎症性肠病患者脑功能网络研究
A study of brain functional networks in patients with inflammatory bowel disease based on graph theory
吴昕橦 1王炳健 1鲍时珍 2卢爽爽 2孙静雯 3岳柯岑 4邹凌 5刘文佳2
作者信息
- 1. 南京医科大学第三附属医院(常州市第二人民医院)消化内科,常州 213003;大连医科大学研究生院,大连 116044
- 2. 南京医科大学第三附属医院(常州市第二人民医院)消化内科,常州 213003
- 3. 南京医科大学第三附属医院(常州市第二人民医院)影像科,常州 213003
- 4. 大连医科大学研究生院,大连 116044;南京医科大学第三附属医院(常州市第二人民医院)影像科,常州 213003
- 5. 常州大学计算机科学与技术学院,常州 213164
- 折叠
摘要
目的 研究炎症性肠病(IBD)患者脑功能网络改变特征,探讨其与临床指标和精神心理评分的相关性.方法 采用横断面调查研究方法.纳入2021年6月至2023年6月在常州市第二人民医院确诊的48例IBD患者,同时选择32例年龄、性别和教育程度相匹配的健康人为健康对照组.采集脑静息状态功能磁共振成像数据,通过图论分析的方法,比较两组受试者脑网络拓扑属性之间的差异,并采用Pearson相关性或Spearman偏相关分析探讨IBD患者脑网络拓扑属性的改变与临床指标、精神心理评分的相关性.结果 IBD组中,男性29例(60.4％),女性19例(39.6％);总病程1.0(0.3,5.0)年;克罗恩病34例,溃疡性结肠炎14例;以活动期为主(58.84％,28/48).IBD患者医院焦虑量表(HADS-A)和医院抑郁量表(HADS-D)量表评分均高于健康对照组(均P＜0.01).全局属性方面,IBD组和健康对照组均具有"小世界"属性(均σ＞1.1).与健康对照组相比,IBD组聚类系数、全局效率、局部效率更低,特征路径长度更长,差异均具有统计学意义(均P＜0.05).局部属性方面,与健康对照组相比,IBD组左侧额中回的度中心性和节点效率更高,左侧丘脑介数中心性更高,右侧海马旁回的介数中心性和度中心性更低,双侧颞中回、右侧前扣带回与旁扣带回的节点聚类系数更低,双侧尾状核和左侧颞中回节点局部效率更低,差异均具有统计学意义(均P＜0.05).IBD组右侧海马旁回的度中心性与HADS-A评分呈负相关(r=-0.401,P=0.005),介数中心性与HADS-A评分呈负相关(r=-0.343,P=0.017).IBD组右侧颞中回节点聚类系数与总病程呈正相关(rs=0.589,P＜0.001).结论 IBD患者脑网络整体信息传输能力下降,边缘系统功能降低,疼痛感知脑区功能异常,且与病程和精神心理状态存在一定相关性.
Abstract
Objective To investigate the characteristics of brain functional networks alterations in patients with inflammatory bowel disease(IBD)and explore their correlations with clinical indicators and psycho-psychological scores.Methods A cross-sectional survey study was conducted.A total of 48 IBD patients diagnosed at the Changzhou Second People's Hospital from June 2021 to June 2023 were collected,and 32 healthy individuals matched for age,gender,and education level were selected as the healthy control group.Resting-state functional magnetic resonance imaging data were enrolled,and the topological properties of brain networks between the two groups of subjects were compared by using graph theory analysis.Pearson correlation and Spearman's partial correlation analyses were used to explore the correlations between changes in IBD patients'brain networks topological properties and clinical indicators and psycho-psychological scores.Results In the IBD group,29 patients were males(60.4％ )and 19 were females(39.6％ );the total disease course was 1.0(0.3,5.0)years;34 patients were Crohn's disease and 14 ulcerative colitis;they were mainly in the active phase(58.84％ ,28/48).The scores of the hospital anxiety and depression scale(HADS-A and HADS-D)in IBD patients were higher than those in the healthy control group(both P＜0.01).In terms of global properties,both the IBD group and the healthy control group had"small-world"properties(both σ＞1.1).Compared with the healthy control group,the IBD group had lower clustering coefficients,global efficiency,and local efficiency,and longer characteristic path lengths,with all differences being statistically significant(all P＜0.05).In terms of local properties,compared with the healthy control group,the IBD group had higher degree centrality and nodal efficiency in the left middle frontal gyrus,higher betweenness centrality in the left thalamus,lower betweenness centrality and degree centrality in the right parahippocampal gyrus,lower nodal clustering coefficients in the bilateral middle temporal gyrus,right anterior cingulate gyrus and paracingulate gyrus,and lower nodal local efficiency in the bilateral caudate nuclei and left middle temporal gyrus,with all differences being statistically significant(all P＜0.05).The degree centrality of the right parahippocampal gyrus in the IBD group was negatively correlated with the HADS-A score(r=-0.401,P=0.005),and the betweenness centrality was also negatively correlated with the HADS-A score(r=-0.343,P=0.017).The nodal clustering coefficient of the right middle temporal gyrus in the IBD group was positively correlated with the total disease course(rs=0.589,P＜0.001).Conclusion IBD patients have decreased overall information transmission capacity in brain networks,reduced limbic system function,and abnormal functions in brain areas related to pain perception,which are correlated to some extent with the disease course and psycho-psychological state.
关键词
炎症性肠病/脑肠轴/磁共振成像/脑功能网络/图论Key words
Inflammatory bowel disease/Gut-brain axis/Magnetic resonance imaging/Brain functional networks/Graph theory引用本文复制引用
基金项目
江苏省委组织部第六期"333人才"项目(苏人才办[2022]21号)
出版年
2024
NETL
NSTL
万方数据