靶向巨噬细胞纳米药物治疗溃疡性结肠炎的研究进展
Recent progress of nanodrugs for treating ulcerative colitis by targeting macrophage
宋诚君 1吴佳敏 1汪芳裕1
作者信息
- 1. 南京大学医学院附属金陵医院消化内科,南京 210002
- 折叠
摘要
溃疡性结肠炎(UC)是一类病因不明,反复发作的慢性肠道炎症.巨噬细胞在UC的发生发展中发挥重要作用.位于肠黏膜组织中的巨噬细胞通过结合上游细胞因子或识别微生物相应配体而活化,并且分泌相关炎性物质进一步加重肠道炎症.因此通过靶向巨噬细胞来治疗UC已经成为当下一个研究热点.纳米药物具有高效性、低毒性和缓释性的特点,近年来靶向巨噬细胞纳米药物治疗UC受到了广泛关注.本文针对各类靶向巨噬细胞的纳米药物构建方法和所调控的生物学机制进行阐述.
Abstract
Ulcerative colitis(UC)is an idiopathic and relapsing inflammatory bowel disease.Previous research has uncovered that macrophages play an indispensable role during the progression of UC.Macrophages in the mucus are stimulated via upstream cytokines or ligands from microorganisms and secrete numerous inflammatory cytokines to exacerbate the colitis.Consequently,precisely modulating macrophages has been an intriguing strategy in UC treatment recently.With the superiority of high efficiency,less toxicity,and sustained release,exploring macrophage-targeted nanodrugs has already become a mainstream approach in UC therapeutics.This review summarizes the strategy of targeting macrophages with nanodrugs and the potential biological mechanisms for UC treatment.
关键词
溃疡性结肠炎/巨噬细胞/靶向/纳米药物Key words
Ulcerative colitis/Macrophage/Target/Nanodrugs引用本文复制引用
出版年
2024
NETL
NSTL
万方数据