炎症性肠病相关支气管扩张的研究进展
Research progress of inflammatory bowel disease-associated bronchiectasis
陈晓敏 1王苏网 1许钊源 2王丽纯 3张扣兴 4陈雷1
作者信息
- 1. 中山大学附属第六医院呼吸与危重症医学科,广州 510655;人体微生态与老年慢性疾病教育部重点实验室,广州 510655;广州市黄埔区中六生物医学创新研究院,广州 510000
- 2. 中山大学附属第六医院消化内科,广州 510655;人体微生态与老年慢性疾病教育部重点实验室,广州 510655;广州市黄埔区中六生物医学创新研究院,广州 510000
- 3. 中山大学附属第六医院重症医学科,广州 510655;人体微生态与老年慢性疾病教育部重点实验室,广州 510655;广州市黄埔区中六生物医学创新研究院,广州 510000
- 4. 中山大学附属第三医院全科医学科,广州 510655
- 折叠
摘要
炎症性肠病(IBD)相关的肺损伤最常累及气道,其中以支气管扩张的发生率最高.同时,在肺部疾病患者中,IBD的发病率呈现出显著上升趋势.这提示IBD与肺部疾病之间可能存在的双向联系,也就是"肺肠轴"的潜在关联.目前IBD相关支气管扩张的发病机制尚不清楚,临床上也缺乏有效的监测和预防手段.因此,本文将IBD相关支气管扩张的发病机制进行阐述,重点探讨在IBD相关支气管扩张背景下肺肠轴的作用,特别是免疫应答和微生物群失衡如何影响肠道和气道的慢性炎症.
Abstract
The pulmonary complications associated with inflammatory bowel disease(IBD)predominantly affect the airways,with bronchiectasis being the most frequently observed condition.Concurrently,there is a notable increase in the prevalence of IBD among individuals with pulmonary disorders.This trend suggests a possible reciprocal relationship between IBD and pulmonary diseases,indicative of the"gut-lung axis"at play.The etiology of bronchiectasis in the context of IBD remains elusive,and there is a dearth of effective clinical tools for monitoring and prevention.This paper delves into the pathogenesis of IBD-related bronchiectasis,with a particular emphasis on the role of the gut-lung axis in this scenario.It scrutinizes the impact of immune responses and dysbiosis of the microbiome on the chronic inflammation observed in both the intestinal tract and the respiratory system.
关键词
支气管扩张/炎症性肠病/免疫调节/微生态失调/肺肠轴Key words
Bronchiectasis/Inflammatory bowel disease/Immune regulation/Microecological imbalance/Lung-gut axis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据