结肠固有层巨噬细胞在溃疡性结肠炎中的作用研究
Roles study of colonic lamina propria macrophages in ulcerative colitis
赵鑫 1姜媛 1但文利 1张慧媛 2李娟 2施京红 3陈丽华2
作者信息
- 1. 陕西中医药大学医学技术学院,咸阳 712046;空军军医大学基础医学院免疫学教研室,西安 710032
- 2. 空军军医大学基础医学院免疫学教研室,西安 710032
- 3. 陕西中医药大学医学技术学院,咸阳 712046
- 折叠
摘要
溃疡性结肠炎(UC)是一种与免疫功能紊乱密切相关的肠道慢性复发性炎性疾病.结肠固有层巨噬细胞是肠黏膜中最为丰富的巨噬细胞群体,能够有效维持和调节肠道内环境的稳定,其介导的炎症反应在UC发生发展中发挥重要作用.本文围绕两种不同亚型的结肠固有层巨噬细胞在UC中的作用机制进行综述,以期为UC的临床治疗提供新思路.
Abstract
Ulcerative colitis(UC)is a chronic relapsing inflammatory disease of the intestine closely associated with immune dysfunction.Colonic lamina propria macrophages are the most abundant population of macrophages in the intestinal mucosa,capable of effectively maintaining and regulating the stability of the intestinal environment.The inflammatory responses mediated by these macrophages play a significant role in the occurrence and development of UC.This article provides a comprehensive review of the roles and mechanisms of two different subtypes of colonic lamina propria macrophages in UC,aiming to provide new insights for the clinical treatment of UC.
关键词
溃疡性结肠炎/巨噬细胞/结肠固有层/细胞因子Key words
Ulcerative colitis/Macrophages/Colonic lamina propria/Cytokine引用本文复制引用
出版年
2024
NETL
NSTL
万方数据