肠道真菌-细菌稳态在炎症性肠病中的意义
Significance of fungus-bacterium homeostasis in inflamma-tory bowel disease
陈思远 1周群燕 1孙静 1许馨文 1陈中霞 1安方梅 1占强1
作者信息
- 1. 南京医科大学附属无锡人民医院消化内科 南京医科大学无锡医学中心,无锡 214023
- 折叠
摘要
炎症性肠病(IBD)是一类以慢性肠道炎症为特征的消化道疾病,包括溃疡性结肠炎和克罗恩病.肠道微生态失调引起的过度持续免疫反应是IBD发生发展的重要机制之一.据统计,肠道微生物类型超过100万亿种,包括细菌、真菌在内的不同微生物体,共同参与能量代谢、肠道屏障功能和免疫平衡.肠道内的真菌与细菌之间存在稳定的协同、拮抗和共生关系,真菌-细菌稳态在维持肠内环境稳态中起重要作用.本文围绕IBD患者肠道真菌变化,基于真菌-细菌稳态的肠道免疫调节及治疗作一综述.
Abstract
Inflammatory bowel disease(IBD)is a group of digestive tract diseases characterized by chronic intestinal inflammation,including ulcerative colitis and Crohn's disease.The over-sustained immune response driven by imbalance of intestinal microbiota plays a key role in the initiation and progression of IBD.Studies have identified that intestinal microbiome possesses more than a hundred trillion types,including bacteria and fungi,which collectively participates in energy metabolism,intestinal barrier function and immune balance.There exists a stable relationship between fungi and bacteria in the intestine,involving cooperation,antagonism,and mutualism.Fungus-bacterium homeostasis plays an important role in maintaining intestinal homeostasis.Based on intestinal fungus changes in IBD patients,this article reviews the research progress in intestinal immunomodulation and therapeutic strategies derived from fungus-bacterial homeostasis.
关键词
炎症性肠病/真菌/细菌/肠道微生态Key words
Inflammatory bowel disease/Fungus/Bacterium/Intestinal microecology引用本文复制引用
基金项目
国家自然科学基金(81800490)
无锡市"双百"拔尖人才项目(BJRC-03)
出版年
2024
NETL
NSTL
万方数据