重视克罗恩病肠道纤维化
Intestinal fibrosis in Crohn's disease
巫晓敏 1王毓 1毛仁1
作者信息
- 1. 中山大学附属第一医院消化内科,广州 510080
- 折叠
摘要
肠道纤维化是慢性炎症导致的细胞外基质过度沉积于肠壁,常见于克罗恩病(CD).肠纤维化会导致肠壁增厚,常引起肠腔狭窄及梗阻等并发症.因缺乏特异的抗纤维化药物,肠狭窄往往需要手术干预,是CD治疗的棘手问题.因此,早期诊断肠纤维化,及时阻止纤维化的进展,是减少肠纤维化导致的不良预后的关键.本文对肠道纤维化的诊断、治疗和机制研究的新进展进行述评,以期为领域提供前沿信息,寻找未来研究方向.
Abstract
Intestinal fibrosis is manifested with excessive deposition of extracellular matrix in the intestinal wall due to chronic inflammation,which is commonly seen in Crohn's disease(CD).Fibrosis can cause intestinal wall thickening,lumen narrowing and obstruction(fibrostricture).However,there is no specific anti-fibrotic drug,and surgery is required to relieve intestinal fibrostricture.To improve the prognosis,intestinal fibrosis should be early diagnosed and timely prevented.This article reviews the progress in the diagnosis,treatment and mechanisms of intestinal fibrosis,in order to provide cutting-edge information and find future research directions.
关键词
克罗恩病/肠道纤维化/爬行脂肪Key words
Crohn's disease/Intestinal fibrosis/Creeping fat引用本文复制引用
出版年
2024
NETL
NSTL
万方数据