通过总结结核分枝杆菌胞外囊泡的生物形成、成分功能，探讨结核分枝杆菌胞外囊泡在诊断、预防和治疗结核病方面的潜力，得出结核分枝杆菌膜囊泡和宿主分泌的外泌体均含有结核分枝杆菌的成分参与免疫调节，在结核病诊断、预防和治疗中发挥不同的作用。结核分枝杆菌胞外囊泡含有丰富的生物标志物，拥有天然的免疫原性，有望成为结核病诊断、预防和治疗的新靶点应用于临床。 By summarizing the biological formation and component function of Mycobacterium tuberculosis extracellular vesicles, this manuscript discusses the potential usage of Mycobacterium tuberculosis extracellular vesicles in diagnosis, prevention, and treatment of tuberculosis. It is concluded that both Mycobacterium tuberculosis membrane vesicles and exosomes secreted by the host contain the components of Mycobacterium tuberculosis to participate in immune regulation, and play different roles in the diagnosis, prevention, and treatment of tuberculosis. Mycobacterium tuberculosis extracellular vesicles contain abundant biomarkers and have natural immunogenicity, which are expected to become new targets for diagnosis, prevention, and treatment of tuberculosis.
Mycobacterium tuberculosis extracellular vesicles: diagnostic, preventive and therapeutic potential
By summarizing the biological formation and component function of Mycobacterium tuberculosis extracellular vesicles, this manuscript discusses the potential usage of Mycobacterium tuberculosis extracellular vesicles in diagnosis, prevention, and treatment of tuberculosis. It is concluded that both Mycobacterium tuberculosis membrane vesicles and exosomes secreted by the host contain the components of Mycobacterium tuberculosis to participate in immune regulation, and play different roles in the diagnosis, prevention, and treatment of tuberculosis. Mycobacterium tuberculosis extracellular vesicles contain abundant biomarkers and have natural immunogenicity, which are expected to become new targets for diagnosis, prevention, and treatment of tuberculosis.
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