狼疮抗凝物（LA）检测是抗磷脂综合征、系统性红斑狼疮实验诊断的重要组成部分，因其为基于凝固时间的检测项目，故LA结果易受多种抗凝药物的干扰。国内实验室在LA检测试剂选择、检测流程、报告方式和结果判断等方面存在着不规范现象，临床医生对LA检测的患者准备和报告解读也存在认识不足等情况。该共识综合国际上各LA检测相关指南的建议及国内现阶段实际应用状况，针对上述问题提出LA检测与报告的指导意见，以期规范国内LA检测流程和报告方式，促进临床医生对LA报告的合理解读与运用，确保相关疾病和临床状况的准确处置。 The detection of lupus anticoagulant (LA) is an important part of laboratory diagnosis for antiphospholipid syndrome and systemic lupus erythematosus. As the test is based on coagulation time, results of LA are sensitive to various anticoagulants. There are widespread irregularities on testing reagent selection, processes, report, and result judgment of LA in domestic laboratories, in addition, there is also a lack of understanding among clinicians regarding patients′ preparation and report interpretation for LA testing. This consensus integrates the recommendations of international LA testing guidelines and the current applicational situations in China, and proposes guidance on LA testing and reporting focusing on the above issues, in order to normalize the domestic LA testing process and reporting, to promote the rational interpretation and application of LA reports by clinicians, consequently to ensure accurate management of related diseases and clinical conditions.
Consensus on normalized testing and reporting of lupus anticoagulant
The detection of lupus anticoagulant (LA) is an important part of laboratory diagnosis for antiphospholipid syndrome and systemic lupus erythematosus. As the test is based on coagulation time, results of LA are sensitive to various anticoagulants. There are widespread irregularities on testing reagent selection, processes, report, and result judgment of LA in domestic laboratories, in addition, there is also a lack of understanding among clinicians regarding patients′ preparation and report interpretation for LA testing. This consensus integrates the recommendations of international LA testing guidelines and the current applicational situations in China, and proposes guidance on LA testing and reporting focusing on the above issues, in order to normalize the domestic LA testing process and reporting, to promote the rational interpretation and application of LA reports by clinicians, consequently to ensure accurate management of related diseases and clinical conditions.
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