Advances in the research of lateral flow assays applied in detecting disease biomarkers
谢浩 1宋昕宇 1孙恩杰 1郭君慧 1干岭
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 武汉理工大学化学化工与生命科学学院，武汉 430070
折叠
摘要
生物标志物具有重要的临床诊断价值。侧流层析技术（LFA）是基于纸层析原理发展起来的检测手段，在疾病生物标志物检测方面有着广泛应用。目前对于LFA的研究主要关注检测特异度、识别精度和灵敏度，以及疾病标志物的多重检测或多疾病的同时检测等方面。该文对LFA的系统设计、工作原理以及在疾病标志物检测中的应用研究进展进行综述，为LFA技术的进一步发展和应用提供参考。 Biomarkers is of great significance for clinical diagnosis. Lateral flow assay (LFA) is a test method which developed based on paper chromatography and has a wide range of applications in testing disease biomarkers. The current researches of LFA mainly focus on the detection specificity, precision and sensitivity, as well as multiple detection of disease markers or simultaneous detection of multiple diseases. This artical reviews the systemic design, working principles of LFA along with the application research of LFA in detecting disease markers, in order to provide reference for development and application of LFA.
Abstract
Biomarkers is of great significance for clinical diagnosis. Lateral flow assay (LFA) is a test method which developed based on paper chromatography and has a wide range of applications in testing disease biomarkers. The current researches of LFA mainly focus on the detection specificity, precision and sensitivity, as well as multiple detection of disease markers or simultaneous detection of multiple diseases. This artical reviews the systemic design, working principles of LFA along with the application research of LFA in detecting disease markers, in order to provide reference for development and application of LFA.
万方数据