目的 探讨性别、年龄、采血时间及季节和 cTnT 检测值变化的相关性。 方法 本研究选取了 2019 年 1月1日至12月31日，复旦大学附属中山医院就诊的 3 548 例非心血管疾病的人群。收集基础资料，包括性别、年龄、采血时间、病史、临床诊断和 cTnT 检测结果，最终入组了男性1 840例，女性1 708例，年龄分布为65（53，75）岁。使用 Kolmogorov-Smirnov（K-S）检验评估数据分布，其中非正态分布的数据以M（Q1，Q3）表示。使用 Mann-Whitney U 检验比较男性与女性之间的 cTnT 浓度，分析性别因素对cTnT检测结果的影响，使用 Kruskal-Wallis 检验比较各性别组之间的 cTnT 水平，分析不同采血时间、季节等因素与 cTnT 浓度的相关性。 结果 在 60 岁以上的人群中，男性和女性的cTnT 浓度均随着年龄的增长而逐渐升高，cTnT 在 90 岁以上的个体中达到最高水平（男性为 0.028 ng/ml，女性为 0.018 ng/ml）。全年龄组分析中显示，男性cTnT 水平（0.012 ng/ml）均高于女性（0.009 ng/ml）（H=6.340，P<0.01）。不同采血时间点的 cTnT 浓度不同。在男性和女性中，cTnT 浓度在 8：00 和 13：00 达到最大值（分别为 0.013 ng/ml 和 0.012 ng/ml）。分析季节对cTnT分泌的生理性影响，结果显示春季和冬季的cTnT 水平（0.012 ng/ml）通常高于夏、秋两季（0.010 ng/ml）。 结论 cTnT 检测值与性别、年龄、采血时间和季节等因素相关。临床工作中分析cTnT检测结果时，应综合考虑个体的性别和年龄，以及采血时间点和季节因素的影响。 Objective To investigate the correlation between gender, age, blood collection time, season and changes in cTnT concentration. Methods In this study, 3548 patients (non-cardiovascular diseases) in Zhongshan Hospital of Fudan University were selected from 1 January to 31 December 2019. The basic data of the patients were collected, including gender, age, time of blood collection, medical history, clinical diagnosis, and results of cTnT testing. 1 840 males and 1 708 females were finally enrolled, with an age distribution of 65 (53, 75) years. The distribution of the data was assessed using the Kolmogorov-Smirnov (K-S) test, where non-normally distributed data were expressed as M(Q1, Q3). The Mann-Whitney U-test was used to compare cTnT concentrations between men and women, and to analyse the influence of gender on cTnT results. The Kruskal-Wallis test was used to compare cTnT levels between gender groups, to analyse the correlation between different times of blood collection, seasons, and other factors and cTnT concentrations. Result cTnT concentrations increased with age in both males and females over the age of 60 years. cTnT levels were highest in individuals over the age of 90 years (0.028 ng/ml in males and 0.018 ng/ml in females). cTnT levels were higher in males (0.012 ng/ml) than in females (0.009 ng/ml) in all age groups (H=6.340,P<0.01). The concentrations of cTnT varied at different time points of blood collection. In both males and females, cTnT concentrations reached a maximum at 8:00 and 13:00 (0.013 ng/ml and 0.012 ng/ml, respectively). Analysis of the physiological effect of season on cTnT secretion showed that cTnT levels were generally higher in spring and winter(0.012 ng/ml) than in summer and autumn(0.010 ng/ml). Conclusions cTnT concentration is influenced by gender, age, time of blood collection and season. When analysing cTnT results in clinical practice, the gender and age of the individual should be taken into account, as well as the time point of blood collection and seasonal factors.
Effect of interindividual biological characteristics and blood collection time on troponin T concentrations
Objective To investigate the correlation between gender, age, blood collection time, season and changes in cTnT concentration. Methods In this study, 3548 patients (non-cardiovascular diseases) in Zhongshan Hospital of Fudan University were selected from 1 January to 31 December 2019. The basic data of the patients were collected, including gender, age, time of blood collection, medical history, clinical diagnosis, and results of cTnT testing. 1 840 males and 1 708 females were finally enrolled, with an age distribution of 65 (53, 75) years. The distribution of the data was assessed using the Kolmogorov-Smirnov (K-S) test, where non-normally distributed data were expressed as M(Q1, Q3). The Mann-Whitney U-test was used to compare cTnT concentrations between men and women, and to analyse the influence of gender on cTnT results. The Kruskal-Wallis test was used to compare cTnT levels between gender groups, to analyse the correlation between different times of blood collection, seasons, and other factors and cTnT concentrations. Result cTnT concentrations increased with age in both males and females over the age of 60 years. cTnT levels were highest in individuals over the age of 90 years (0.028 ng/ml in males and 0.018 ng/ml in females). cTnT levels were higher in males (0.012 ng/ml) than in females (0.009 ng/ml) in all age groups (H=6.340,P<0.01). The concentrations of cTnT varied at different time points of blood collection. In both males and females, cTnT concentrations reached a maximum at 8:00 and 13:00 (0.013 ng/ml and 0.012 ng/ml, respectively). Analysis of the physiological effect of season on cTnT secretion showed that cTnT levels were generally higher in spring and winter(0.012 ng/ml) than in summer and autumn(0.010 ng/ml). Conclusions cTnT concentration is influenced by gender, age, time of blood collection and season. When analysing cTnT results in clinical practice, the gender and age of the individual should be taken into account, as well as the time point of blood collection and seasonal factors.
万方数据
