液相色谱-串联质谱技术具有高特异性、高通量的特点，因此在临床检验领域有快速的应用和发展，其在治疗药物监测中的应用可有效提升定量准确性与灵敏度，为患者制定个性化的最佳给药方案。但该技术目前仍面临一些挑战，自动化、质量控制、量值溯源等将是今后的发展方向。 Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology has the characteristics of high specificity and high throughput, making it rapidly applied and developed in the field of clinical testing. Its application in the monitoring of therapeutic drugs can effectively improve the quantitative accuracy and sensitivity, and formulate a personalized and optimal dosing plan for patients. However, this technology still faces some challenges, and automation, quality control, and quantitative traceability will be the future development direction.
Abstract
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology has the characteristics of high specificity and high throughput, making it rapidly applied and developed in the field of clinical testing. Its application in the monitoring of therapeutic drugs can effectively improve the quantitative accuracy and sensitivity, and formulate a personalized and optimal dosing plan for patients. However, this technology still faces some challenges, and automation, quality control, and quantitative traceability will be the future development direction.
关键词
色谱法,液相/串联质谱法/治疗药物监测/样本前处理/挑战
Key words
Chromatography, liquid/Tandem mass spectrometry/Therapeutic drug monitoring/Sample pretreatment/Challenge
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