The occurrence and development of human malignancies is often accompanied by epigenetic changes,and DNA methylation is one of the most common epigenetic modification.Methylation events are often discovered in the early stage of gynecologic neoplasia.The methylation detection protocol based on liquid biopsy technology has made important progress in the screening and prognosis assessment of gynecologic tumors.The reliability of methylation detection in micro-noninvasive samples from multiple sources is similar to or better than that of traditional protocols and strategies.This article reviews the progress of methylation detection in screening,diagnosis and monitoring of gynecologic tumors,and discusses its value in the present and future diagnosis and treatment of gynecologic tumors.
关键词
DNA甲基化/妇科肿瘤/筛查/诊断/预后
Key words
DNA methylation/Gynecologic tumor/Screening/Diagnosis/Prognosis
维普
万方数据